England dropped veteran paceman Stuart Broad for this current match to play express quicks Jofra Archer and Mark Wood together for the first time in a Test.
But Archer and Wood struggled to make an impression on a placid pitch.
They took just one wicket between them in a combined 44 overs - and that was only when Wood bowled last man Shannon Gabriel to end the innings.
West Indies resumed behind closed doors on 57-1, with the first sunny blue skies of the match providing ideal conditions for batting.
Barbados-born Archer nearly had Shai Hope lbw for 16 but a West Indies review revealed a no-ball.
Hope, however, was still on 16 when he edged off-spinner Dom Bess to first slip where Stokes, captaining England in the absence of Joe Root, held a sharp catch.
It was an encouraging moment for Stokes, who could have been forgiven for second-guessing himself after deciding to bat first on winning the toss.
But, as he has so often done before, Stokes made a vital breakthrough when he trapped Brathwaite in front of the stumps.
Shamarh Brooks made a promising 39 before he was caught behind off James Anderson, with England's all-time leading Test wicket-taker returning figures of 3-62.
Jermaine Blackwood gave his wicket away by driving Bess (2-51) straight to Anderson at mid-off.
Dowrich, however, drove Bess for two fours in three balls before, on 25, he hammered a drive the Somerset bowler could only parry.
Roston Chase drove the first delivery with the new ball, from Wood, for four before he was lbw to Anderson for a defiant 47 off 142 balls.
Following his bowling heroics on Thursday, Holder said he wanted to score a Test hundred in England as well.
But he fell in single figures when, undone by a surprise bouncer, he hooked Stokes straight to Archer at long leg.